Basal Ganglia: Striosomes and the Link between Motivation and Action
| Autor: | Richard Courtemanche, Amanda Cammalleri |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Functional role Habenula Motivation Biology Basal Ganglia Corpus Striatum Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine nervous system Action (philosophy) Basal ganglia Animals Macaca General Agricultural and Biological Sciences Link (knot theory) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Biology. 29:R62-R65 |
| ISSN: | 0960-9822 |
| Popis: | Striosomes, neurochemically specialized modules in the striatum, are thought to be nodes in circuits extending, via basal ganglia pathways, from mood-related neocortical regions to dopamine-containing neurons of the substantia nigra. Yet striosomes have remained beyond the reach of electrophysiological methods to identify them, especially in non-human primates. Such work is needed for translational as well as for basic science. Here we introduce a method to identify striosomes on-line, in awake, behaving macaques. We combined electrical microstimulation of the striatum with simultaneous electrophysiological recording in the lateral habenula, followed by immunohistochemistry. We demonstrate that striosomes provide the predominant striatal input to the macaque pallido-habenular circuit, known to function in relation to reinforcement signaling. Further, our experiments suggest that striosomes from different striatal regions may convergently influence the lateral habenula. This work now opens the way to defining the functions of striosomes in behaving primates in relation to mood, motivation and action. |
| Databáze: | OpenAIRE |
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