Synthesis and characterization of complexes of trialkyl- and triarylphosphine gold(I) with thiolated purines and pyrimidines. A class of bifunctional compounds with potential antitumor activity
| Autor: | C. Frank Shaw, Anvarhusein A. Isab, Giancarlo Stocco, Filippa Gattuso |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Antitumor activity
Bicyclic molecule Dithioerythritol Stereochemistry Chemistry chemistry.chemical_element Biological activity Nuclear magnetic resonance spectroscopy Sulfur Biochemistry Combinatorial chemistry Inorganic Chemistry chemistry.chemical_compound Materials Chemistry Physical and Theoretical Chemistry Binding site Purine metabolism Bifunctional Phosphine |
| Zdroj: | Journal of Inorganic Biochemistry. 43:616 |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/0162-0134(91)84587-y |
| Popis: | New complexes of the type R 3 PAuL or (R 3 PAu) 2 (μ-L) where R=ethyl or phenyl and L=6-thioguanine, 2, 6- dithioxanthine, 2, 4-dithiouracil and/or dithioerythritol have been prepared. These complexes have been identified by using elemental analysis, 1 H, 13 C and 31 P NMR spectroscopy. The structures have been proposed based on these spectroscopic studies. Sulfur appears to be the binding site in disubstituted complexes of 2, 4-dithiouracil and 1, 4-dithioerythritol, while the phosphine gold( I ) moieties appear to be S and N bonded in 2, 6-dithioxanthine and 6-thioguanine. The potential use of these complexes as antitumor drugs is discussed. |
| Databáze: | OpenAIRE |
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