Effect of weight change and lifestyle modifications on the development or remission of nonalcoholic fatty liver disease: sex-specific analysis
| Autor: | Naoki Yoshioka, Hajime Sumi, Takanori Ito, Takashi Honda, Takeo Yamaguchi, Yoji Ishizu, Teiji Kuzuya, Jun Ichi Haruta, Yasuko Watanabe, Tetsuya Ishikawa, Masao Doisaki, Masatoshi Ishigami, Mitsuhiro Fujishiro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Multivariate analysis lcsh:Medicine Weight Gain digestive system Article Body Mass Index 03 medical and health sciences Liver disease 0302 clinical medicine Weight loss Behavior Therapy Non-alcoholic Fatty Liver Disease Internal medicine Nonalcoholic fatty liver disease Weight Loss Medicine Humans Longitudinal Studies lcsh:Science Exercise Life Style Non-alcoholic steatohepatitis Multidisciplinary business.industry Weight change lcsh:R Remission Induction nutritional and metabolic diseases Odds ratio Middle Aged medicine.disease digestive system diseases 030104 developmental biology 030211 gastroenterology & hepatology lcsh:Q Female medicine.symptom business Body mass index Weight gain Risk Reduction Behavior |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
| ISSN: | 2045-2322 |
| Popis: | The effects of changes in various lifestyle habits on nonalcoholic fatty liver disease (NAFLD) have not been well elucidated. We aimed to clarify how weight change and lifestyle modifications were associated with the development or remission of NAFLD. In this longitudinal cohort study, we reviewed the periodic health checkup data of 1,421 subjects with no causes of liver disease besides NAFLD who had received at least two health checkups between 2009 and 2018. The prevalence of NAFLD at baseline was 34.1% (484/1,421). During follow-up period (4.6 ± 2.8 years), 104 subjects developed NAFLD and 127 subjects demonstrated NAFLD remission. The frequency of NAFLD development or that of NAFLD remission significantly increased as the larger weight gain or weight loss was, respectively (both, p |
| Databáze: | OpenAIRE |
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