DICHOTOMOUS EFFECT OF AEROSOLIZED HYALURONAN IN A HAMSTER MODEL OF ENDOTOXIN-INDUCED LUNG INJURY

Autor:	Jerome O. Cantor, Girish S. Kulkarni, Shuren Ma, Joseph M. Cerreta, Priya P. Nadkarni
Rok vydání:	2005
Předmět:	Pulmonary and Respiratory Medicine Neutrophils Clinical Biochemistry Hamster Apoptosis Lung injury Proinflammatory cytokine Cricetinae medicine Animals Hyaluronic Acid Respiratory system Lung Molecular Biology Aerosols Mesocricetus Inhalation business.industry Respiratory disease respiratory system medicine.disease Endotoxins medicine.anatomical_structure Receptors Tumor Necrosis Factor Type I Immunology Toxicity business
Zdroj:	Experimental Lung Research. 31:807-818
ISSN:	1521-0499 0190-2148
Popis:	Inhalation of aerosolized low-molecular-weight (150-kDa) hyaluronan (HA) was previously shown by this laboratory to prevent experimentally induced pulmonary emphysema without associated toxicity. Nevertheless, other investigators have found that low-molecular-weight HA may be proinflammatory, prompting the authors to determine if aerosolized HA could possibly enhance pulmonary inflammation in a different model of lung injury involving intratracheal instillation of endotoxin to hamsters. Results indicate that exposure to HA following endotoxin administration significantly increased lung inflammation, whereas pretreatment with HA had the opposite effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b474ecfafa2ef68d3171a41c54595e48 https://doi.org/10.1080/01902140600574942 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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