Prenatal Environmental Exposure to Persistent Organic Pollutants and Reproductive Hormone Profile and Pubertal Development in Dutch Adolescents
| Autor: | Sietske A. Berghuis, Arend F. Bos, Henk Groen, Wilhelmina H. A. de Jong, Anneke C. Muller Kobold, Lucie Wagenmakers-Huizinga, Pieter J. J. Sauer, Gianni Bocca |
|---|---|
| Přispěvatelé: | Reproductive Origins of Adult Health and Disease (ROAHD), Value, Affordability and Sustainability (VALUE), Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Adolescent Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Environmental Exposure Polychlorinated Biphenyls adolescence adolescent chemical exposure endocrine disruptor persistent organic pollutant polychlorinated biphenyl prenatal exposure pubertal development reproductive hormone testosterone Hormones Persistent Organic Pollutants Maternal Exposure Pregnancy Prenatal Exposure Delayed Effects Humans Environmental Pollutants Female Child |
| Zdroj: | International Journal of Environmental Research and Public Health; Volume 19; Issue 15; Pages: 9423 International Journal of Environmental Research and Public Health, 19(15). MDPI AG |
| ISSN: | 1661-7827 |
| Popis: | Persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), may interfere with hormonal processes. Knowledge about the effects of prenatal exposure to PCBs and their hydroxylated metabolites (OH-PCBs) on pubertal development is limited. Therefore, the aim of the current study was to determine whether prenatal environmental PCB and OH-PCB exposure are associated with reproductive hormone levels and pubertal characteristics in 13- to 15-year-old children. In this Dutch observational cohort study, 194 mother–infant pairs were included (1998–2002). Maternal pregnancy serum levels of PCBs, OH-PCBs, and other POPs were measured. At follow-up (2014–2016), we measured serum or plasma levels of reproductive hormones in their children. We assessed Tanner stages and testicular volume (by clinician or standardized self-assessment), and participants completed questionnaires on pubertal onset. In total, 101 adolescents (14.4 ± 0.8 years; 53.7% of invited) participated, and 55 were boys. In boys, higher prenatal PCB levels were associated with higher testosterone levels, higher pubic hair stage, larger testicular volume, and younger age at onset of growth spurt and voice break. In girls, higher prenatal PCB levels were associated with higher stages for breast development. In conclusion, higher prenatal PCB exposure could be associated with more advanced pubertal development in 13- to 15-year-old children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|