18FDG PET versus high-dose 67Ga scintigraphy for restaging and treatment follow-up of lymphoma patients
| Autor: | Bieke Lambert, R. A. J. O. Dierckx, C. Van de Wiele, F De Winter, A Kolindou, B. Van Den Bossche, L. Noens |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Adolescent Gallium FDG-Positron Emission Tomography Single-photon emission computed tomography Scintigraphy Sensitivity and Specificity law.invention Positron Fluorodeoxyglucose F18 law medicine Humans Radiology Nuclear Medicine and imaging Citrates Neoplasm Staging Gamma camera medicine.diagnostic_test business.industry Lymphoma Non-Hodgkin General Medicine Gold standard (test) Middle Aged medicine.disease Hodgkin Disease Lymphoma Bone marrow examination Cross-Sectional Studies Female Radiopharmaceuticals Nuclear medicine business Follow-Up Studies Tomography Emission-Computed |
| Zdroj: | Nuclear Medicine Communications. 23:1079-1083 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-200211000-00007 |
| Popis: | To date, only one published study has directly compared 67 Ga scintigraphy (low dose, planar) with planar dual-head gamma camera 18 F-fluorodeoxyglucose ( 18 FDG) imaging for the purpose of treatment follow-up monitoring in lymphoma patients, and no data on restaging are available. The present study reports the direct comparison of high-dose (297-370 MBq) 67 Ga planar and single photon emission computed tomography (SPECT) imaging and conventional 18 FDG positron emission tomography (PET) for restaging and treatment follow-up of lymphoma patients versus a gold standard consisting of morphological imaging, including plain radiography and computed tomography (CT) scanning, bone marrow examination and long-term follow-up ( < 12 months). Sixteen patients, 10 with non-Hodgkin's lymphoma and six with Hodgkin's disease, were included (10 men, six women; median age, 43 years; range, 16-64 years). The median follow-up time was 27 months (range, 12-34 months). In two patients, 67 Ga and 18 FDG PET (370 MBq) were performed twice, resulting in 18 cross-sectional episodes. In 11 episodes, the results obtained by both imaging modalities were in agreement with regard to the presence or absence of disease when compared with the gold standard. However, the abnormalities found on 18 FDG PET were always more extensive. In two episodes, 67 Ga imaging normalized after treatment, whereas PET showed significant regression followed by subsequent normalization. In four additional episodes, 67 Ga images were negative, whereas FDG PET visualized non-tumour-related pathology, such as lung infection, rib fracture or dense thymic tissue. In one gold standard-negative patient, the underlying cause of sternal FDG uptake remained undetermined. The data presented, although limited in number, suggest that 18 FDG PET performs better than 67 Ga imaging in monitoring lymphoma disease status. However, a correlation with clinical history and a knowledge of the characteristics of benign lesions are mandatory. Further studies are recommended. |
| Databáze: | OpenAIRE |
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