Visual extinction in relation to visuospatial neglect after right-hemispheric stroke: quantitative assessment and statistical lesion-symptom mapping
| Autor: | Philipp Eschenbeck, Gereon R. Fink, Jochen Saliger, Peter H. Weiss, Ralph Weidner, Simone Vossel, Hans Karbe |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty media_common.quotation_subject Posterior parietal cortex Neuropsychological Tests Audiology Severity of Illness Index Functional Laterality Neglect Perceptual Disorders diagnosis [Perceptual Disorders] Parietal Lobe Visual extinction medicine Cluster Analysis Humans complications [Stroke] ddc:610 Stroke media_common physiopathology [Parietal Lobe] Parietal lobe physiopathology [Frontal Lobe] standards [Neuropsychological Tests] social sciences Middle Aged medicine.disease humanities Frontal Lobe Psychiatry and Mental health statistics & numerical data [Neuropsychological Tests] Pattern Recognition Visual Frontal lobe Space Perception Extinction (neurology) etiology [Perceptual Disorders] Female Surgery Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry 82, 862-868 (2011). doi:10.1136/jnnp.2010.224261 |
| ISSN: | 0022-3050 |
| Popis: | Background Visual neglect and extinction are two common neurological syndromes in patients with right-hemispheric brain damage. Whether and how these two syndromes are associated or share common neural substrates is still a matter of debate. Methods To address these issues, the authors investigated 56 patients with right-hemispheric stroke with a novel diagnostic test to detect extinction and neglect. In this computerised task, subjects had to respond to target stimuli in uni- and bilateral stimulation conditions with detection probabilities being assessed. A cluster-analytical approach identified 18 patients with neglect and 13 patients with extinction. Statistical lesion-symptom mapping analyses with measures for extinction and neglect were performed. Results Extinction and neglect co-occurred in a subset of patients but were also observed independently from each other, thereby constituting a double dissociation. Lesions within the right inferior parietal cortex were significantly associated with the severity of visual extinction. Visuospatial neglect was related to damage of fronto-parietal brain regions, with parieto-occipital areas affecting line bisection and dorsal fronto-parietal areas affecting cancellation task performance, respectively. Conclusion Quantifying lesion-induced symptoms with this novel paradigm shows that extinction and neglect are dissociable syndromes in patients with right-hemispheric stroke. Furthermore, extinction and neglect can be related to differential neural substrates, with extinction being related to focal brain damage within the right inferior parietal cortex. |
| Databáze: | OpenAIRE |
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