Handwriting in patients with Parkinson's disease: Effect of L-Dopa and stimulation of the sub-thalamic nucleus on motor anticipation
| Autor: | Valérie Fraix, Jean-Pierre Orliaguet, Sonia Kandel, Christel Bidet-Ildei, Pierre Pollak |
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| Přispěvatelé: | Laboratoire de Psychologie et NeuroCognition (LPNC), Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), GIPSA - Systèmes Linguistiques et Dialectologie (GIPSA-SLD), Département Parole et Cognition (GIPSA-DPC), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Université de Poitiers |
| Předmět: |
Male
Handwriting Psychomotor Performance/drug effects/physiology medicine.medical_treatment Deep Brain Stimulation Stimulation Disease Audiology Antiparkinson Agents Levodopa 0302 clinical medicine Parkinson Disease/diagnosis/drug therapy/physiopathology Reference Values Orthopedics and Sports Medicine Attention [SHS.LANGUE]Humanities and Social Sciences/Linguistics ComputingMilieux_MISCELLANEOUS Neurologic Examination 05 social sciences Parkinson Disease General Medicine Middle Aged Anticipation Thalamic nucleus Attention/drug effects/physiology Female Psychology Adult medicine.medical_specialty Antiparkinson Agents/therapeutic use Deep brain stimulation Biophysics Experimental and Cognitive Psychology 050105 experimental psychology 03 medical and health sciences Neurologic Examination/drug effects Subthalamic Nucleus Reaction Time/drug effects/physiology medicine Reaction Time Computer Graphics Humans 0501 psychology and cognitive sciences In patient Levodopa/therapeutic use Anticipation Psychological/drug effects/physiology Anticipation Psychological ddc:616.8 Institutional repository Subthalamic Nucleus/physiology Neuroscience 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | HAL Human Movement Science Human Movement Science, Elsevier, 2011, 30 (4), pp.783-791. ⟨10.1016/j.humov.2010.08.008⟩ Human Movement Science, Vol. 30, No 4 (2011) pp. 783-91 |
| ISSN: | 0167-9457 |
| DOI: | 10.1016/j.humov.2010.08.008⟩ |
| Popis: | The present research focused on how patients with Parkinson's disease (PD) produce handwriting sequences. PD patients who were on/off medication or deep brain stimulation treatments had to write lll and lln trigrams. We evaluated their ability to anticipate on-line the last letter in the trigram. The results revealed that in PD patients, contrary to healthy participants, the percentage of time taken by the down-stroke of the second l did not vary as a function of the spatial constraints of the following letter (l or n). In other words, the handwriting of the PD patients did not exhibit any sign of motor anticipation. However, under treatment, PD patients exhibited similar results to healthy participants despite no improvement in movement variability. Taken together these results do not seem consistent with the hypothesis that PD patients do not anticipate future movements because of their movement variability. They are more in agreement with theories that postulate that PD patients have a general deficit in the parallel processing of the components of a motor sequence. |
| Databáze: | OpenAIRE |
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