Vitamin E dependent microRNA regulation in rat liver
| Autor: | Jan Frank, Constance Schmelzer, Frank Doering, Sonja Gaedicke, Xiangnan Zhang, Gerald Rimbach, Yijia Lou |
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| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Biophysics Inflammation Biology Biochemistry Structural Biology Internal medicine microRNA Gene expression Genetics medicine Animals Vitamin E Tocopherol Molecular Biology Regulation of gene expression Messenger RNA Base Sequence Lipid metabolism MicroRNA Cell Biology Lipid Metabolism Rats Inbred F344 Diet Rats MicroRNAs Endocrinology Cell Transformation Neoplastic Gene Expression Regulation Liver Rat medicine.symptom Post-transcriptional gene regulation |
| Zdroj: | FEBS Letters. (23-24):3542-3546 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2008.09.032 |
| Popis: | Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA-122a; cancer and inflammation, miRNA-125b). VE-deficiency resulted in reduced concentrations of miRNA-122a and miRNA-125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo. |
| Databáze: | OpenAIRE |
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