Cross-sectional study of aortic valve calcification and cardiovascular risk factors in older Danish men

Autor: Flemming Hald Steffensen, Jes S. Lindholt, Marek Karon, Axel Cosmus Pyndt Diederichsen, Jess Lambrechtsen, Lida Khurrami, Kenneth Egstrup, Maise Høigaard Fredgart, Grazina Urbonaviciene, Jacob E. Møller, Lars Frost, Martin Buske
Rok vydání: 2021
Předmět:
Male
PREDICTION
Cross-sectional study
Denmark
medicine.medical_treatment
PROGRESSION
heart valve diseases
ANGIOGRAPHY
Severity of Illness Index
Coronary artery disease
Valve replacement
Prevalence
risk factors
ASSOCIATIONS
education.field_of_study
Calcinosis
Middle Aged
Cardiovascular Diseases
Aortic Valve
Aortic valve calcification
Cardiology and Cardiovascular Medicine
coronary artery disease
CORONARY-ARTERY CALCIFICATION
Calcinosis/diagnosis
medicine.medical_specialty
diagnostic imaging
Population
Renal function
Risk Assessment
STENOSIS
CALCIUM
EVENTS
Internal medicine
Diabetes mellitus
medicine
SERUM PHOSPHATE
Humans
COMPUTED-TOMOGRAPHY
Risk Assessment/methods
education
Aged
business.industry
Cardiovascular Diseases/epidemiology
Aortic Valve Stenosis
medicine.disease
Aortic Valve Stenosis/diagnosis
Obesity
Denmark/epidemiology
Aortic Valve/diagnostic imaging
Cross-Sectional Studies
Heart Disease Risk Factors
coronary angiography
Tomography
X-Ray Computed
business
Zdroj: Khurrami, L, Møller, J E, Lindholt, J S, Urbonaviciene, G, Steffensen, F H, Lambrechtsen, J, Karon, M, Frost, L, Buske, M, Egstrup, K, Fredgart, M H & Diederichsen, A C P 2021, ' Cross-sectional study of aortic valve calcification and cardiovascular risk factors in older Danish men ', Heart, vol. 107, no. 19, pp. 1536-1543 . https://doi.org/10.1136/heartjnl-2021-319023
ISSN: 1468-201X
1355-6037
DOI: 10.1136/heartjnl-2021-319023
Popis: ObjectiveAortic valve calcification (AVC) and coronary artery calcification (CAC) are predictors of cardiovascular disease (CVD), presumably sharing risk factors. Our objectives were to determine the prevalence and extent of AVC in a large population of men aged 60–74 years and to assess the association between AVC and cardiovascular risk factors including CAC and biomarkers.MethodsParticipants from the DANish CArdioVAscular Screening and intervention trial (DANCAVAS) with AVC and CAC scores and without previous valve replacement were included in the study. Calcification scores were calculated on non-contrast CT scans. Cardiovascular risk factors were self-reported, measured or both, and further explored using descriptive and regression analysis for AVC association.Results14 073 men aged 60–74 years were included. The AVC scores ranged from 0 to 9067 AU, with a median AVC of 6 AU (IQR 0–82). In 8156 individuals (58.0%), the AVC score was >0 and 215 (1.5%) had an AVC score ≥1200. In the regression analysis, all cardiovascular risk factors were associated with AVC; however, after inclusion of CAC ≥400, only age (ratio of expected counts (REC) 1.07 (95% CI 1.06 to 1.09)), hypertension (REC 1.24 (95% CI 1.09 to 1.41)), obesity (REC 1.34 (95% CI 1.20 to 1.50)), known CVD (REC 1.16 (95% CI 1.03 to 1.31)) and serum phosphate (REC 2.25 (95% CI 1.66 to 3.10) remained significantly associated, while smoking, diabetes, hyperlipidaemia, estimated glomerular filtration rate and serum calcium were not.ConclusionsAVC was prevalent in the general population of men aged 60–74 years and was significantly associated with all modifiable cardiovascular risk factors, but only selectively after adjustment for CAC ≥400 AU.Trial registration numberNCT03946410 and ISRCTN12157806.
Databáze: OpenAIRE
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