Additive‐free Aqueous Dispersions of Two‐Dimensional Materials with Glial Cell Compatibility and Enzymatic Degradability
| Autor: | Abhay Pandit, Kenneth Lobo, Priyabrata Sahoo, Rajendra Kurapati, K. Vijaya Krishna, H. S. S. Ramakrishna Matte, Vaibhav Patil |
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| Rok vydání: | 2021 |
| Předmět: |
Bioelectronics
010405 organic chemistry Organic Chemistry Water chemistry.chemical_element General Chemistry Biodegradation Spectrum Analysis Raman 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences symbols.namesake chemistry Chemical engineering Transition metal Molybdenum symbols Humans Degradation (geology) Raman spectroscopy Neuroglia Nanosheet |
| Zdroj: | Chemistry – A European Journal. 27:7434-7443 |
| ISSN: | 1521-3765 0947-6539 |
| DOI: | 10.1002/chem.202005491 |
| Popis: | Water-dispersible two-dimensional (2D) materials are desirable for diverse applications. Aqueous dispersions make processing safer and greener and enable evaluation of these materials on biological and environmental fronts. To evaluate the effects of 2D materials with biological systems, obtaining dispersions without additives is critical and has been a challenge. Herein, a method was developed for obtaining additive-free aqueous dispersions of 2D materials like transition metal dichalcogenides and hexagonal boron nitride (h-BN). The nanosheet dispersions were investigated through spectroscopic and microscopic methods, along with the role of size on stability. The aqueous media enabled investigations on cytocompatibility and enzymatic degradation of molybdenum disulphide (MoS2 ) and h-BN. Cytocompatibility with mixed glial cells was observed up to concentrations of 100 μg mL-1 , suggesting their plausible usage in bioelectronics. Besides, biodegradation using human myeloperoxidase (hMPO) mediated catalysis was investigated through Raman spectroscopy and electron microscopy. The findings suggested that additive-free 2H-MoS2 and h-BN were degradable by hMPO, with 2H-phase exhibiting better resistance to degradation than the 1T-phase, while h-BN exhibited slower degradation. The findings pave a path for incorporating 2D materials in the burgeoning field of transient bioelectronics. |
| Databáze: | OpenAIRE |
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