The association between transthoracic echocardiogram parameters and white matter hyperintensities
| Autor: | Adam de Havenon, Ka-Ho Wong, Majd Ibrahim, Eric D. Goldstein, Kayla S. Navarro |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Heart Ventricles Hemodynamics Normal values 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Heart Atria Stroke Aged Retrospective Studies Ejection fraction business.industry Confounding Brain General Medicine Middle Aged medicine.disease White Matter Hyperintensity Echocardiography 030220 oncology & carcinogenesis Cardiac chamber Cerebral Small Vessel Diseases cardiovascular system Cardiology Surgery Female Neurology (clinical) Transthoracic echocardiogram business 030217 neurology & neurosurgery |
| Zdroj: | Clinical neurology and neurosurgery. 206 |
| ISSN: | 1872-6968 |
| Popis: | Objective Identify abnormal cardiac chamber size and hemodynamic parameters on transthoracic echocardiogram (TTE) as predictors of advancing cerebral small vessel disease (CSVD) on brain magnetic resonance imaging (MRI). Materials and methods A retrospective chart review of adults with a brain MRI and a 2-dimensional TTE was performed. WMH measured by the Fazekas score served as the primary outcome. We fit multivariate ordinal logistic regression models to the Fazekas score with the individual predictors of the TTE measurements and adjusted for potential confounders. Results 132 individuals were included. Cardiac functional markers were not significant, including tricuspid annular plane systolic excursion (p = 0.818), right ventricular ejection fraction (p = 0.818) and left ventricular ejection fraction (p = 0.673). Cardiac structural markers included right atrial area (p = 0.247), right ventricular internal diameter (RVID, p = 0.020) and left atrial area (LAA, p = 0.041). RVID and LAA were identified as being predictors, although the direction of the association suggested that normal values resulted in more WMH. Analysis of isolated DWM or PVWM Fazekas scores were not associated with cardiac structure or function. Conclusions In our study, we found that normal LAA and RVID values were associated with an increased degree of WMH on MRI. This finding may represent earlier identification of WMH prior to TTE cardiac changes. Future studies are needed for more robust quantitative comparison as well as evaluation prospectively of the association between cardiac chamber sizes and development of WMH. |
| Databáze: | OpenAIRE |
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