Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
| Autor: | Carolina Moreira Blanco, Marcus V. G. Lacerda, Josué da Costa Lima-Junior, Evelyn Ketty Pratt Riccio, João Hermínio Martins da Silva, Ana Carolina Ramos Guimarães, Rodrigo Medeiros de Souza, Jenifer Peixoto de Barros, Gisely Cardoso de Melo, Paulo Renato Rivas Totino, Barbara de Oliveira Baptista, Hugo Amorim dos Santos de Souza, Victor Fernandes Escafa, Lilian Rose Pratt-Riccio, Cláudio Tadeu Daniel-Ribeiro, Fabio Faria da Mota, Aline Beatriz Mello Rodrigues |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_treatment Short Communication RC955-962 030231 tropical medicine Plasmodium vivax Protozoan Proteins Biology Microbiology 03 medical and health sciences Complete sequence 0302 clinical medicine Arctic medicine. Tropical medicine Catalytic Domain parasitic diseases medicine Malaria Vivax P. vivax Humans Histidine Genetics Genetic diversity Protease Strain (biology) Genetic Variation genetic diversity medicine.disease biology.organism_classification QR1-502 Metacaspase metacaspase Malaria Brazil |
| Zdroj: | Memórias do Instituto Oswaldo Cruz Memórias do Instituto Oswaldo Cruz., Vol 116 (2021) |
| ISSN: | 1678-8060 0074-0276 |
| Popis: | In the present study, we investigated the genetic diversity of Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain in two municipalities of the main malaria hotspot in Brazil, i.e., the Juruá Valley, and observed complete sequence identity among all P. vivax field isolates and the Sal-1 reference strain. Analysis of PvMCA1 catalytic domain in different P. vivax genomic sequences publicly available also revealed a high degree of conservation worldwide, with very few amino acid substitutions that were not related to putative histidine and cysteine catalytic residues, whose involvement with the active site of protease was herein predicted by molecular modeling. The genetic conservation presented by PvMCA1 may contribute to its eligibility as a druggable target candidate in vivax malaria. |
| Databáze: | OpenAIRE |
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