Dietary fatty acids and bioactive fatty acid metabolites in alcoholic liver disease
| Autor: | Kara Zirnheld, Irina A. Kirpich, Jeffrey Warner, Craig J. McClain, Josiah E. Hardesty, Dennis R. Warner |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Alcoholic liver disease Hepatology Linoleic acid Gastroenterology Fatty acid medicine.disease Eicosapentaenoic acid 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Biochemistry Docosahexaenoic acid medicine lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology lcsh:RC799-869 Steatohepatitis Steatosis Polyunsaturated fatty acid |
| Zdroj: | Liver Research, Vol 3, Iss 3, Pp 206-217 (2019) |
| ISSN: | 2542-5684 |
| DOI: | 10.1016/j.livres.2019.10.001 |
| Popis: | Alcoholic liver disease (ALD) comprises a spectrum of liver pathology, including steatosis, steatohepatitis, and cirrhosis. Previous work from our group and others suggests that dietary fat, both the amount and composition, plays a pivotal role in ALD development and progression; however, the impact of specific dietary fatty acids on ALD pathogenesis is not fully elucidated. Preclinical rodent models of ALD revealed the deleterious effects of omega-6 polyunsaturated fatty acids (n-6 PUFAs), specifically linoleic acid (LA), and this may be partially attributed to the increased levels of pro-inflammatory oxidized LA metabolites. There is limited understanding regarding the role of omega-3 polyunsaturated fatty acids (n-3 PUFAs, such as alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid), and bioactive n-3 PUFA-derived lipid molecules in ALD. Given that majority of n-6 and n-3 PUFAs-derived metabolites are potent endogenous signaling molecules, knowledge regarding the changes in these lipid mediators may shed new light on the mechanisms contributing to ALD pathogenesis and reveal novel therapeutic targets and biomarkers of this disease. The current review summarizes relevant scientific literature regarding the role of dietary fat, distinct fatty acids, and bioactive fatty acid metabolites in ALD, and highlights recent advances in the field. Keywords: Dietary fatty acids, Bioactive fatty acid metabolites, Alcoholic liver disease (ALD), Omega-6 polyunsaturated fatty acids (n-6 PUFAs), Omega-3 polyunsaturated fatty acids (n-3 PUFAs) |
| Databáze: | OpenAIRE |
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