| Autor: |
Susan Geyer, Mayumi Maki, Kyoji Furukawa, Tomonori Hayashi, Yoichiro Kusunoki, Alvin Shi, Kengo Yoshida, Kei Nakachi, Hiroko Nagamura, Junko Kajimura, Waka Ohishi, Keiko Sasaki, Ivo D. Shterev, Yiqun Hu, Ana Lustig, Yukari Morishita, Seishi Kyoizumi, Nan ping Weng, Ikue Hayashi |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Oncotarget |
| ISSN: |
1949-2553 |
| Popis: |
Ionizing radiation (IR) is a major source of cellular damage and the immediate cellular response to IR has been well characterized. But the long-term impact of IR on cell function and its relationship with aging are not known. Here, we examined the IR effects on telomere length and other biomarkers 50 to 68 years post-exposure (two time points per person) in survivors of the atomic bombing at Hiroshima during WWII. We found that telomere length of leukocytes was inversely correlated with the dose of IR (p=0.008), and this effect was primarily found in survivors who were exposed at younger ages; specifically those |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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