Analysis of allele segregation distortion in a swine resource family
| Autor: | Hirohide Uenishi, Y. Wada, S. Mikawa, H. Yasue |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Genetics
Litter (animal) Genetic Markers Male Swine Chromosome Chromosome Mapping Sequence Homology Bioengineering Biology Genome Pedigree Family member Embryonic and Fetal Development Genetic marker Mutation Animals Humans Animal Science and Zoology Female Göttingen Miniature pig Allele Gene Alleles Biotechnology |
| Zdroj: | Animal biotechnology. 10(3) |
| ISSN: | 1049-5398 |
| Popis: | Segregation distortion of alleles was found in several regions of the genome in allele type analyses of genetic markers for a swine resource family that had been constructed by crossing Göttingen miniature pig and Meishan breeds. From these regions, a region on chromosome 6 presented a distortion over several consecutive markers. This chromosome 6 region was subsequently further investigated to reveal that alleles of a chromosome 6 homologue of the Gottingen miniature pig were not found in a homozygous family member. The litter size of F1-crosses which were able to produce homozygotes in this region were 24% smaller, on average, than F1-crosses which were unable to produce homozygotes. This indicated that this region of the chromosome 6 homologue contained a recessive gene or genes which could terminate fetal development. An additional 10 markers were subsequently used to investigate the region more precisely. These studies revealed that this region spans 7 cM and is located between markers Sw855 and Sw122. Since current comparative maps show that this region corresponds to the human chromosome 19 q-arm, genes positioned on the human chromosome 19 q-arm were screened to select 20 candidate genes. These included the pregnancy-specific beta-1-glycoprotein gene. |
| Databáze: | OpenAIRE |
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