Neuro-nutrients as anti-alzheimer's disease agents: A critical review
| Autor: | S. Ravi, Ramesh B Narasingappa, Bruno Vincent |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Mediterranean diet
030309 nutrition & dietetics Nutritional Status Disease Bioinformatics medicine.disease_cause Neuroprotection Industrial and Manufacturing Engineering Neuro inflammation 03 medical and health sciences 0404 agricultural biotechnology Nutrient Alzheimer Disease Fatty Acids Omega-3 Humans Medicine Dementia Nutritional Physiological Phenomena 0303 health sciences Anti alzheimer business.industry Vitamins 04 agricultural and veterinary sciences General Medicine medicine.disease 040401 food science Diet Anti-Anxiety Agents business Oxidative stress Food Science |
| Zdroj: | Critical Reviews in Food Science and Nutrition. 59:2999-3018 |
| ISSN: | 1549-7852 1040-8398 |
| DOI: | 10.1080/10408398.2018.1481012 |
| Popis: | Alzheimer's disease (AD) is characterized by a massive neuronal death causing memory loss, cognitive impairment and behavioral alteration that ultimately lead to dementia and death. AD is a multi-factorial pathology controlled by molecular events such as oxidative stress, protein aggregation, mitochondrial dysfunction and neuro inflammation. Nowadays, there is no efficient disease-modifying treatment for AD and epidemiological studies have suggested that diet and nutrition have a significant impact on the development of this disorder. Indeed, some nutrients can protect all kind of cells, including neurons. As prevention is better than cure, life style improvement, with a special emphasis on diet, should seriously be considered as an anti-AD track and intake of nutrients promoting neuronal health is the need of the hour. Diets rich in unsaturated fatty acids, polyphenols and vitamins have been shown to protect against AD, whereas saturated fatty acids-containing diets deprived of polyphenols promote the development of the disease. Thus, Mediterranean diets, mainly composed of fruits, vegetables and omega-3 fatty acids, stand as valuable, mild and preventive anti-AD agents. This review focuses on our current knowledge in the field and how one can fight this devastating neurodegenerative disorder through the simple proper modification of our life style. |
| Databáze: | OpenAIRE |
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