Effects of ısotretinoin on the growth rate and thickness of the nail plate
| Autor: | Sinan Özçelik, Fatma Arzu Kiliç |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Life quality
Dentistry Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences Nail Diseases 0302 clinical medicine Acne Vulgaris Medicine Humans skin and connective tissue diseases Isotretinoin Acne integumentary system business.industry Nail plate Onychoschizia medicine.disease medicine.anatomical_structure Nails 030220 oncology & carcinogenesis NAIL GROWTH Nail (anatomy) Quality of Life Nail Changes business medicine.drug |
| Zdroj: | International journal of dermatologyReferences. 60(10) |
| ISSN: | 1365-4632 |
| Popis: | BACKGROUND Isotretinoin has various effects on nails. However, the mechanism of how isotretinoin affects the nail plate is unknown. We aimed to investigate the effects of isotretinoin on morphology, growth rate, and thickness of the nail plate. METHODS A total of 70 acne vulgaris patients treated with isotretinoin and a control group consisting of 68 healthy volunteers were included in the study. Isotretinoin treatment was started at a dose of 0.5 mg/kg per day. Nail changes were noted; length and thickness of the nail plate were measured in all participants every month. RESULTS The medians of nail growth rates in the isotretinoin and control groups were 3.16 (2.87-3.57) mm/month and 2.89 (2.56-3.19) mm/month, respectively. The medians of nail thickness in the isotretinoin and control groups were 0.47 (0.38-0.53) mm and 0.50 (0.40-0.65) mm, respectively. Statistically significant differences were observed between the groups in terms of nail growth rate and thickness (P |
| Databáze: | OpenAIRE |
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