Nonlinear shell behavior of phospholipid-coated microbubbles
| Autor: | Valeria Garbin, M.L.J. Overvelde, Benjamin Dollet, Michel Versluis, Nico de Jong, Jeroen Sijl, Detlef Lohse |
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| Přispěvatelé: | Institute for Biomedical Technology (MIRA), University of Twente, Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Cardiology, Physics of Fluids, Faculty of Science and Technology, University of Twente [Netherlands], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Materials science
Acoustics and Ultrasonics Acoustics Bubble Biophysics Shell (structure) Contrast Media Viscoelastic Substances MESH: Ultrasonics 01 natural sciences Resonance Viscoelasticity 030218 nuclear medicine & medical imaging Physics::Fluid Dynamics 03 medical and health sciences 0302 clinical medicine Coated Materials Biocompatible MESH: Coated Materials Biocompatible MESH: Contrast Media 0103 physical sciences Phospholipid coating Ultrasonics Radiology Nuclear Medicine and imaging MESH: Viscoelastic Substances Sound pressure 010301 acoustics Phospholipids Ultrasonography MESH: Phospholipids Microbubbles Radiological and Ultrasound Technology Nonlinear bubble dynamics Mechanics Ultrasound contrast agents 3. Good health [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biophysics Nonlinear system IR-73962 Buckling METIS-272789 MESH: Microbubbles MESH: Ultrasonography |
| Zdroj: | Ultrasound in Medicine & Biology Ultrasound in Medicine & Biology, 2010, 36 (12), pp.2080-92. ⟨10.1016/j.ultrasmedbio.2010.08.015⟩ Ultrasound in Medicine and Biology, 36(12), 2080-2092. Elsevier Inc. Ultrasound in medicine and biology, 36(12), 2080-2092. Elsevier Ultrasound in Medicine & Biology, Elsevier, 2010, 36 (12), pp.2080-92. ⟨10.1016/j.ultrasmedbio.2010.08.015⟩ |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2010.08.015⟩ |
| Popis: | The influence of the stabilizing phospholipid-coating on the nonlinear dynamics of ultrasound contrast agent microbubbles is investigated. We record the radial dynamics of individual microbubbles with an ultra high-speed camera as a function of both driving pressure and frequency. The viscoelastic shell was found to enhance the nonlinear bubble response at acoustic pressures as low as 10 kPa. For increasing acoustic pressures a decrease of the frequency of maximum response was observed for a distinct class of bubbles, leading to a pronounced skewness of the resonance curve, which we show to be the origin of the "thresholding" behavior (Emmer et al. 2007). For the other bubbles, the frequency of maximum response was found to lie just above the resonance frequency of an uncoated microbubble and to be independent of the applied acoustic pressure. The shell-buckling bubble model (Marmottant et al. 2005), which accounts for buckling and rupture of the shell, captures both cases for a unique set of the shell parameters, the relevant parameter being the phospholipid concentration at the bubble interface. (E-mail: m.versluis@utwente.nl) (C) 2010 World Federation for Ultrasound in Medicine & Biology. |
| Databáze: | OpenAIRE |
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