Profound hyperferritinemia may not be specific for the diagnosis of haemophagocytic lymphohistiocytosis (HLH) in Asian children
| Autor: | Mei Yoke Chan, Clement K M Ho, Prasad Iyer, Ragavendra Kalyanasundaram, Rajat Bhattacharyya, Wen Qi Cher |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Pediatrics medicine.medical_specialty Ferritin levels Population 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine education Paediatric patients Ferritin education.field_of_study Asian biology business.industry lcsh:RJ1-570 Haemophagocytic lymphohistiocytosis (HLH) lcsh:Pediatrics Retrospective cohort study Hematology Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health biology.protein business 030215 immunology Paediatric population |
| Zdroj: | Pediatric Hematology Oncology Journal, Vol 5, Iss 3, Pp 96-99 (2020) |
| ISSN: | 2468-1245 |
| DOI: | 10.1016/j.phoj.2020.07.001 |
| Popis: | Profound hyperferritinaemia of >10,000 μg/L has been suggested to be highly specific for the diagnosis of paediatric haemophagocytic lymphohistiocytosis (HLH) in western literature but similar studies are lacking in Asian children. We did a single-centre retrospective study analysing paediatric patients with a ferritin value of >500 mcg/L admitted to a children’s hospital in Singapore between January 2010 and December 2015. Sensitivity and specificity of ferritin for diagnosing HLH were analyzed at various ferritin levels. The finding of hyperferritinemia has a much lower specificity for HLH in our Asian paediatric population compared to Western population as it is also a finding in many infective and inflammatory conditions. Thus, while ferritin remains a good screening marker, it is not specific for HLH and other clinical and laboratory parameters should be considered prior to initiating HLH-specific treatment. |
| Databáze: | OpenAIRE |
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