Approach to cytological indeterminate thyroid nodules
| Autor: | Giancarlo Troncone, Massimo Bongiovanni, Claudio Bellevicine, Gerasimos P. Sykiotis |
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| Přispěvatelé: | Bongiovanni, Massimo, Bellevicine, Claudio, Troncone, Giancarlo, Sykiotis, Gerasimos P |
| Rok vydání: | 2019 |
| Předmět: |
Thyroid nodules
follicular neoplasm or suspicious for a follicular neoplasm (FN/SFN) medicine.medical_specialty 030209 endocrinology & metabolism Review Article Atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) medicine.disease_cause indeterminate diagnosi Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine indeterminate diagnosis the Bethesda system thyroid fine-needle aspiration cytology (thyroid FNAC) Medicine Thyroid neoplasm business.industry Thyroid medicine.disease Bethesda system for reporting thyroid cytopathology Aspiration cytology medicine.anatomical_structure 030220 oncology & carcinogenesis Surgery Radiology business Indeterminate Who classification |
| Zdroj: | Gland surgery, vol. 8, no. Suppl 2, pp. S98-S104 |
| ISSN: | 2227-8575 2227-684X |
| DOI: | 10.21037/gs.2018.12.06 |
| Popis: | The indeterminate thyroid nodules diagnosed by fine-needle aspiration cytology (FNAC)represents a problem for both cytopathologists and clinicians. The former sometimes use this diagnostic category as a sort of basket, putting in cases that they do not know exactly how to classify. The latter are faced with a highly variable risk of malignancy and consequently the management remains a challenge. On the histopathological side, the new WHO classification of tumors of the thyroid introduced the concept of tumors with uncertain and low malignant potential, and the concept of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), whose prognosis and management are still to be completely elucidated. While the risk of malignancy of the indeterminate diagnostic category has decreased due to the re-classification of certain types of papillary thyroid carcinomas of the follicular variant into a low malignant potential form (the NIFTP), cases diagnosed cytologically as indeterminate will probably increase in the future to avoid false positive diagnosis. Thus, the indeterminate thyroid diagnostic category still remains a challenge, both at the diagnostic level and for its management. The new version of the Bethesda system for reporting thyroid cytopathology suggests managing these patients with a repeat FNA, diagnostic lobectomy and/or molecular testing. |
| Databáze: | OpenAIRE |
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