Long term retention and excretion of 201Tl in a patient after myocardial perfusion imaging

Autor: C. Challeton-de Vathaire, D. Celier, S. Cassot, Eric Blanchardon, G. Herbelet, D. Franck, Jean-René Jourdain, J.-C. Martin, A. Biau, P. Boisson
Přispěvatelé: Laboratoire d'évaluation de la dose interne (DRPH/SDI/LEDI), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
Jazyk: angličtina
Rok vydání: 2005
Předmět:
radiation detector
Male
urinalysis
[SDV]Life Sciences [q-bio]
tissue distribution
Myocardial Ischemia
Urine
radiation detection
Effective dose (radiation)
030218 nuclear medicine & medical imaging
0302 clinical medicine
Urinary excretion
heart function
dose response
Medicine
Thallium
gamma spectrometry
Radiation
Radiological and Ultrasound Technology
medicine.diagnostic_test
article
General Medicine
3. Good health
bioassay
drug excretion
030220 oncology & carcinogenesis
radioactivity
radiation measurement
Biological half-life
radiation dose
whole body counter
thallium 201
heart muscle perfusion
Urinalysis
Metabolic Clearance Rate
chemistry.chemical_element
urinary excretion
Excretion
03 medical and health sciences
Myocardial perfusion imaging
radioisotope distribution
coronary artery bypass graft
half life time
Coronary Circulation
case report
follow up
Humans
Radiology
Nuclear Medicine and imaging
human
Radionuclide Imaging
Aged
business.industry
Public Health
Environmental and Occupational Health
Biological Transport
Thallium Radioisotopes
chemistry
sodium iodide
functional assessment
heart scintiscanning
Radiopharmaceuticals
business
Nuclear medicine
Zdroj: RADIATION PROTECTION DOSIMETRY
RADIATION PROTECTION DOSIMETRY, 2005, 113 (1), pp.47-53. ⟨10.1093/rpd/nch430⟩
DOI: 10.1093/rpd/nch430⟩
Popis: 201Tl is widely used in nuclear medicine to carry out myocardial perfusion imaging (MPI). However, very limited data is available on long-term distribution in the body, excretion and corresponding dose. In this study we performed a 2 month follow-up of a patient who underwent MPI, by urine analysis and in vivo measurements. The biological half-life of thallium was consequently estimated to be 11.6-27 d, which is in partial agreement with previous studies. We also estimated excretion and retention of 200Tl, 201Tl and 202Tl isotopes using the biokinetic parameters from ICRP publication 53 and compared the forecast result with actual measurements. The latter demonstrated a higher urinary excretion and a higher body retention than what was expected. Our results therefore suggest that the long-term retention and consequently the effective dose coefficient for 201Tl considered in ICRP publications 53 and 80 may be slightly underestimated. © The Author 2005. Published by Oxford University Press. All rights reserved.
Databáze: OpenAIRE
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