Prenatal markers of atypical neurodevelopment in children with congenital heart defects
| Autor: | Isabelle Boucoiran, Laurence Carmant, Mélodie Mathe, Christine Boutin, Ala Birca, Lucie Morin |
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| Rok vydání: | 2021 |
| Předmět: |
Heart Defects
Congenital Pediatrics medicine.medical_specialty business.industry Obstetrics and Gynecology Infant 030204 cardiovascular system & hematology Alberta Cohort Studies 03 medical and health sciences 0302 clinical medicine Increased risk Motor delay Pregnancy 030225 pediatrics Pediatrics Perinatology and Child Health medicine Neurodevelopmental delay Humans Female business Child Retrospective Studies |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 35(25) |
| ISSN: | 1476-4954 |
| Popis: | A growing body of literature demonstrates that survivors of congenital heart defects (CHD) are at increased risk of neurodevelopmental delay, which frequently manifests as motor delay during the first year of life.The aim of this study was to determine prenatal predictors of an early atypical neurodevelopment. This information could help assist decision-making during prenatal counseling.In this retrospective cohort study, we evaluated the records of 75 children with CHD followed at theForty-four infants (58.7%) had atypical neurodevelopment. When there was no extra cardiac anomaly seen on prenatal ultrasound, a head to abdominal ratio (HC/AC) below 1.1 was associated with a four-fold increased risk of atypical neurodevelopment (OR = 4.54; 95% CI = 1.24-16.64Our study shows that early atypical neurodevelopment affects the majority of children with CHD and highlights the importance of post-natal monitoring by a specialized team. A thorough prenatal ultrasound is important to screen for those at higher risk i.e. those with extra cardiac anomaly and HC/AC below 1.1. A larger cohort is needed to validate those results. |
| Databáze: | OpenAIRE |
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