The Added Value of Tau-PET in the Assessment of Progressive Supranuclear Palsy
| Autor: | Diego Alfonso López-Mora, Alberto Lleó, Rafael Blesa, Alejandro León, Valle Camacho |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty Aminopyridines tau Proteins 030218 nuclear medicine & medical imaging Progressive supranuclear palsy Akinetic rigid syndrome 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Cognitive impairment Clinical syndrome Aged business.industry Neurodegeneration General Medicine medicine.disease eye diseases Supranuclear palsy 030220 oncology & carcinogenesis Positron-Emission Tomography Quinolines Supranuclear Palsy Progressive business |
| Zdroj: | Clinical nuclear medicine. 45(5) |
| ISSN: | 1536-0229 |
| Popis: | Progressive supranuclear palsy (PSP) is rare neurodegenerative disorder characterized by deposition of fibrillar aggregates of 4R tau-protein in neurons and glial cells. This disorder is underdiagnosed due to the overlap of the clinical syndrome with other related conditions. The clinical manifestations include cognitive impairment associated with behavioral changes, akinetic rigid syndrome, and prominent oculomotor dysfunction. We present the F-FDG and F-THK5351 PET images of a 71-year-old man diagnosed of probable PSP. This image highlights the hopeful results of the new tau-PET ligands radiotracers, because it allows to assess the distribution of tau-protein over time, closely associated with neurodegeneration in PSP. |
| Databáze: | OpenAIRE |
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