Serum Myeloperoxidase Activity, Total Antioxidant Capacity and Nitric Oxide Levels in Patients with Chronic Otitis Media
| Autor: | Mehmet Fatih Garça, Bakır Tuna, Mehmet Aslan, Hakan Çankaya, Ahmet Kozan |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant Adolescent Physiology medicine.medical_treatment education Total antioxidant capacity Biophysics Nitric Oxide medicine.disease_cause Antioxidants Article Nitric oxide 4-Hydroxynonenal Pathogenesis Lipid peroxidation Young Adult chemistry.chemical_compound Malondialdehyde Internal medicine medicine Humans Chronic otitis media Child Cholesteatoma Peroxidase Aldehydes biology Myeloperoxidase activity Cell Biology Oxidants Otitis Media Oxidative Stress Endocrinology chemistry Biochemistry Case-Control Studies Myeloperoxidase Chronic Disease biology.protein Female Lipid Peroxidation Oxidation-Reduction Oxidative stress |
| Zdroj: | The Journal of Membrane Biology |
| ISSN: | 0022-2631 |
| DOI: | 10.1007/s00232-013-9561-8 |
| Popis: | It has been suggested that oxidative stress may play an important role in the pathogenesis of chronic otitis media (COM), but the role of oxidative stress in the pathogenesis of COM has not yet been fully explored. Therefore, the aim of this study was to investigate serum myeloperoxidase (MPO) activity, 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), total antioxidant capacity (TAC) and nitric oxide (NO) in patients with COM. Sixty-one patients with COM and 30 controls were enrolled in the present study. Patients were divided into two groups according to the presence (n=21) or absence (n=40) of cholesteatoma. Serum MPO activity and 4-HNE, MDA and NO levels were significantly higher in patients with COM than controls (for all,ppp>0.05). Increased oxidative stress seems to be associated with decreased antioxidant levels in patients with COM. Thus, increased oxidative stress may play a role in the pathogenesis of COM. It is believed that the administration of antioxidant vitamins such as A, C and E may be useful in preventing and treating COM.KeywordsChronic otitis mediaCholesteatomaMyeloperoxidase activity4-HydroxynonenalMalondialdehydeTotal antioxidant capacityNitric oxide |
| Databáze: | OpenAIRE |
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