| Autor: |
Lucio Tremolizzo, Daniele Selvatico, Federico Emanuele Pozzi, Diletta Cereda, Jacopo Cosimo DiFrancesco, Lorenzo Fumagalli, Carlo Ferrarese, Ildebrando Appollonio |
| Přispěvatelé: |
Tremolizzo, L, Selvatico, D, Pozzi, F, Cereda, D, Difrancesco, J, Fumagalli, L, Ferrarese, C, Appollonio, I |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 43(10) |
| ISSN: |
1590-3478 |
| Popis: |
Introduction Neurological soft signs (NSS) are subtle non-localizing sensorimotor abnormalities initially reported as increased in primary headache patients. The aims of this study were confirming with full power NSS increased expression in migraine and, collaterally, determining if psychiatric traits or white matter lesions at brain imaging could influence this result. Methods Forty drug-free episodic migraine outpatients (MH) were recruited with 40 matched controls. NSS were determined by the 16-item Heidelberg scale; depression, anxiety and QoL by the HAM-D; the STAI-X1/X2; and the SF36, respectively. The Fazekas scale on brain MR studies was applied in n = 32 MH, unravelling deep white matter signal alterations (DWM). MH characteristics, including the headache disability inventory (HDI), were recorded. Results NSS were 46% increased in MH vs. controls (p = 0.0001). HAM-D and STAI-X1/X2 were increased in MH, while SF36 was unchanged, but they all failed to influence NSS, just as MH characteristics. NSS scores were increased in MH-DWM + (n = 11, + 85%) vs. MH-DWM − (n = 21, + 27%) vs. controls (p Discussion/conclusions NSS are increased in MH and probably not influenced by the affective status, possibly marking a dysfunction within the cerebellar-thalamic-prefrontal circuit that may deserve further attention from the prognostic point of view. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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