Assessment of four experimental models of hyperlipidemia
| Autor: | Bennia Alfonso Cáceres, María de los Ángeles Boffill Cárdenas, Emoe Betancourt Morgado, Orestes Castillo Alfonso, Maibia Tamayo Irsula, Yisel González Madariaga |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Sucrose medicine.medical_specialty Hyperlipidemias Poloxamer Mice chemistry.chemical_compound Internal medicine Hyperlipidemia medicine Animals Nonionic surfactant Dietary supplementation Rats Wistar General Veterinary Triglyceride business.industry nutritional and metabolic diseases medicine.disease Animal Feed Lipids Diet Rats Mice Inbred C57BL Disease Models Animal Endocrinology chemistry Dietary Supplements Blood cholesterol lipids (amino acids peptides and proteins) Animal Science and Zoology business |
| Zdroj: | Lab Animal. 44:135-140 |
| ISSN: | 1548-4475 0093-7355 |
| DOI: | 10.1038/laban.710 |
| Popis: | Various animal models of hyperlipidemia are used in research. Four rodent hyperlipidemia experimental models are examined in this study: three chronic hyperlipidemia models based on dietary supplementation with lipid or sucrose for 3 months and one acute hyperlipidemia model based on administration of the nonionic surfactant poloxamer. Neither lipid supplementation nor sucrose supplementation in Wistar rats was effective for establishing hyperlipidemia. Combining both lipid and sucrose supplementation in BALB/c mice induced hypercholesterolemia, as reflected in a considerable increase in blood cholesterol concentration, but did not produce an increase in blood triglyceride concentration. Poloxamer administration in C57BL/J6 mice produced increases in blood cholesterol and triglyceride concentrations. The authors conclude that supplementation of both lipid and sucrose in BALB/c mice was the most effective method for developing chronic hypercholesterolemia. |
| Databáze: | OpenAIRE |
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