Modified chemotactic peptides: Synthesis and activity of an azaTic-containing fMLP-OMe analogue
| Autor: | I. Torriai, M. Paghalunga Paradisi, G. Mastropietro, Susanna Spisani, Gino Lucente, G. Pagani Zecchini |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
Magnetic Resonance Spectroscopy Stereochemistry Organic Chemistry Clinical Biochemistry Carboxylic Acids Chemotaxis Biological activity Phenylalanine Limiting Biochemistry Combinatorial chemistry Amino acid N-Formylmethionine Leucyl-Phenylalanine Chemotaxis Leukocyte Residue (chemistry) Bioactive peptide Models Chemical chemistry Side chain Phthalazines |
| Zdroj: | Amino Acids. 14:301-309 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/bf01318849 |
| Popis: | The synthesis and the biological activity of a pseudopeptide analogue of the chemotactic N-formyltripeptide fMLP-OMe, containing the azaTic (3,4-dihydro-2(1H)-phthalazinecarboxylic acid) residue replacing the native phenylalanine, is described. Whereas pseudopeptides containing linear alpha-azaamino acids are currently studied, data on the new group of analogues containing cyclic alpha-aza residues capable of limiting the rotameric distribution of the side chains (topological control) are just emerging in the literature. At our best knowledge, the here described [azaTic3]fMLP-OMe represents the first example of the introduction of this new type of alpha-aza residue into a natural bioactive peptide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink