Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement
| Autor: | Anthony M. D. Lee, Geoffrey Hohert, Sylvia Lam, Renelle Myers, Stephen Lam, Pierre M. Lane, Andrei Vertikov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Paper
Image-Guided Biopsy Swine Biomedical Engineering Lung biopsy autofluorescence 01 natural sciences Imaging 010309 optics Biomaterials Optical coherence tomography In vivo 0103 physical sciences Biopsy medicine Animals biopsy optical coherence tomography medicine.diagnostic_test business.industry Biopsy Needle Optical Imaging animal study Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Stylet Autofluorescence Feasibility Studies business Nuclear medicine Tomography Optical Coherence Preclinical imaging Ex vivo lung imaging |
| Zdroj: | Journal of Biomedical Optics |
| ISSN: | 1083-3668 |
| DOI: | 10.1117/1.jbo.25.10.106003 |
| Popis: | Significance: Diagnosis of suspicious lung nodules requires precise collection of relevant biopsies for histopathological analysis. Using optical coherence tomography and autofluorescence imaging (OCT-AFI) to improve diagnostic yield in parts of the lung inaccessible to larger imaging methods may allow for reducing complications related to the alternative of computed tomography-guided biopsy. Aim: Feasibility of OCT-AFI combined with a commercially available lung biopsy needle was demonstrated for visualization of needle puncture sites in airways with diameters as small as 1.9 mm. Approach: A miniaturized OCT-AFI imaging stylet was developed to be inserted through an 18G biopsy needle. We present design considerations and procedure development for image-guided biopsy. Ex vivo and in vivo porcine studies were performed to demonstrate the feasibility of the procedure and the device. Results: OCT-AFI scans were obtained ex vivo and in vivo. Discrimination of pullback site is clear. Conclusions: Use of the device is shown to be feasible in vivo. Images obtained show the stylet is effective at providing structural information at the puncture site that can be used to assess the diagnostic potential of the sample prior to collection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|