Application of ultraviolet, visible, and infrared light imaging in protein-based biopharmaceutical formulation characterization and development studies
| Autor: | Jürgen Hubbuch, Marieke E. Klijn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Infrared Chemistry Pharmaceutical Pharmaceutical Science Nanotechnology 02 engineering and technology medicine.disease_cause 030226 pharmacology & pharmacy 03 medical and health sciences Chemical engineering 0302 clinical medicine Drug Development Drug Stability Image processing Protein analytics Formulation development Machine learning medicine Biological Products Future perspective Protein Stability Optical Imaging High-throughput screening Residual moisture Proteins General Medicine 021001 nanoscience & nanotechnology Characterization (materials science) Biopharmaceutical ddc:660 Computer vision 0210 nano-technology Ultraviolet Biotechnology |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics, 165, 319-336 European Journal of Pharmaceutics and Biopharmaceutics, 165 |
| ISSN: | 0939-6411 1873-3441 |
| Popis: | Imaging is increasingly more utilized as analytical technology in biopharmaceutical formulation research, with applications ranging from subvisible particle characterization to thermal stability screening and residual moisture analysis. This review offers a comprehensive overview of analytical imaging for scientists active in biopharmaceutical formulation research and development, where it presents the unique information provided by the ultraviolet (UV), visible (Vis), and infrared (IR) sections in the electromagnetic spectrum. The main body of this review consists of an outline of UV, Vis, and IR imaging techniques for several (bio)physical properties that are commonly determined during protein-based biopharmaceutical formulation characterization and development studies. The review concludes with a future perspective of applied imaging within the field of biopharmaceutical formulation research. |
| Databáze: | OpenAIRE |
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