Cytokine Patterns Associated with a Serotype 8 Fowl Adenovirus Infection
| Autor: | Hamid R. Haghighi, Helena Grgić, Éva Nagy, Shayan Sharif |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adenoviridae Infections
medicine.medical_treatment Immunology Spleen Biology Real-Time Polymerase Chain Reaction Cecum Immune system Virology medicine Animals Interferon gamma Poultry Diseases Aviadenovirus Gene Expression Profiling Interleukin Gene expression profiling medicine.anatomical_structure Real-time polymerase chain reaction Cytokine Liver Cytokines Molecular Medicine Chickens medicine.drug |
| Zdroj: | Viral Immunology. 26:143-149 |
| ISSN: | 1557-8976 0882-8245 |
| DOI: | 10.1089/vim.2012.0078 |
| Popis: | This study examined cytokine gene expression patterns associated with fowl adenovirus (FAdV) infection. The selected cytokine mRNA was quantified by quantitative real-time reverse transcription-PCR in spleen, liver, and cecal tonsil during the course of infection of chickens with a serotype 8 FAdV (FAdV-8). Compared to uninfected chickens, infected birds had higher mRNA expression of interleukin (IL)-18 and IL-10 in spleen and liver, respectively. Interferon gamma (IFN-γ) mRNA expressed in spleen and liver of infected chickens was significantly upregulated, while the expression of IL-8 mRNA in spleen and liver of infected chickens was significantly downregulated. There was no significant difference between infected and uninfected groups in terms of cytokine gene expression in cecal tonsil. These results indicate that these four cytokines might play an important role in driving the immune responses following FAdV-8 infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|