Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways

Autor:	Hamidreza Zalpoor, Maryam Bakhtiyari, Hooriyeh Shapourian, Puria Rostampour, Chanour Tavakol, Mohsen Nabi-Afjadi
Rok vydání:	2022
Předmět:	Pharmacology SARS-CoV-2 Hesperidin Neoplasms Immunology Humans Pharmacology (medical) Signal Transduction COVID-19 Drug Treatment
Zdroj:	Inflammopharmacology. 30(5)
ISSN:	1568-5608
Popis:	Hesperetin, an aglycone metabolite of hesperidin with high bioavailability, recently gained attention due to its anti-COVID-19 and anti-cancer properties. Multiple studies revealed that cancer patients are prone to experience a severe form of COVID-19 and higher mortality risk. In addition, studies suggested that COVID-19 can potentially lead to cancer progression through multiple mechanisms. This study proposes that hesperetin not only can be used as an anti-COVID-19 agent but also can reduce the risk of multiple cancer progression by suppressing several intracellular signaling pathways in cancer patients with COVID-19. Therefore, in this review, we attempted to provide evidence demonstrating anti-COVID-19/cancer properties of hesperetin with several mechanisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45040d74758e1f62b18eb7a59ed0bb0 https://pubmed.ncbi.nlm.nih.gov/35994216 Zobrazit plný text záznamu Full text from SpringerLink