Genetic control of pituitary development and hypopituitarism
| Autor: | Gratien G. Prefontaine, Jessica Tollkuhn, Michael G. Rosenfeld, Xiaoyan Zhu, Chijen R. Lin |
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| Rok vydání: | 2005 |
| Předmět: |
Pituitary gland
medicine.medical_specialty Cell signaling Pituitary disorder Hypopituitarism Biology Internal medicine Genetics medicine Animals Humans Transcription factor Zebrafish Gene Expression Regulation Developmental medicine.disease biology.organism_classification Forward genetics medicine.anatomical_structure Endocrinology Hypothalamus Pituitary Gland Neuroscience Signal Transduction Transcription Factors Developmental Biology |
| Zdroj: | Current Opinion in Genetics & Development. 15:332-340 |
| ISSN: | 0959-437X |
| DOI: | 10.1016/j.gde.2005.04.011 |
| Popis: | The pituitary gland functions as a relay between the hypothalamus and peripheral target organs that regulate basic physiological functions, including growth, the stress response, reproduction, metabolism and lactation. The development of the pituitary gland has been studied extensively in mice, and has begun to be explored in zebrafish, an animal model system amenable to forward genetics. Multiple signaling molecules and transcription factors, expressed in overlapping but distinct spatial and temporal patterns, are required at various stages of pituitary development. Defects in this precisely regulated genetic program lead to diverse pituitary dysfunction. The animal models have greatly enhanced our understanding of molecular mechanisms underlying pituitary development in addition to congenital pituitary disorders in humans. |
| Databáze: | OpenAIRE |
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