IL-6 levels are dramatically high in the sputum from children with sickle cell disease during acute chest syndrome

Autor:	Rachel Rignault-Bricard, Slimane Allali, Jean-Marc Talbot, Valentine Brousse, Florence Moulin, Olivier Hermine, Joséphine Brice, Melissa Taylor, Claire Heilbronner, Mariane de Montalembert, Thiago Trovati Maciel
Rok vydání:	2020
Předmět:	medicine.medical_specialty Cell CCL3 Anemia Sickle Cell Disease CCL2 Gastroenterology Internal medicine Acute Chest Syndrome medicine Humans Child Interleukin 6 biology Interleukin-6 business.industry Sputum Hematology respiratory system medicine.disease Stimulus Report Acute chest syndrome respiratory tract diseases medicine.anatomical_structure biology.protein medicine.symptom business
Zdroj:	Blood Adv
ISSN:	2473-9537 2473-9529
Popis:	Key Points Sputum interleukin-6 (IL-6) level is high during acute chest syndrome (ACS) in pediatric sickle cell disease, supporting anti–IL-6 trials. Sputum IL-8, CCL2, and CCL3 levels are also high during ACS, possibly contributing to recruitment of inflammatory cells in the lungs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44dfbb9e2dea5666356a5fc5b0ef6a2 https://doi.org/10.1182/bloodadvances.2020003519 Zobrazit plný text záznamu