Additional file 4 of DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence

Autor: Lista, María José, Jousset, Anne-Caroline, Cheng, Mingpan, Saint-André, Violaine, Perrot, Elouan, Rodrigues, Melissa, Di Primo, Carmelo, Gadelle, Danielle, Toccafondi, Elenia, Segeral, Emmanuel, Berlioz-Torrent, Clarisse, Emiliani, Stéphane, Mergny, Jean-Louis, Lavigne, Marc
Rok vydání: 2023
DOI: 10.6084/m9.figshare.23264988.v1
Popis: Additional file 4: Figure S4. No G4 enrichment is observed in the positive or negative strands of TOP1 activated genes of HCT116 cells. G4 predictions in the promoter sequence of human genes repressed by Top1. Boxplots of G4 maximum scoresin positive or negative strand at the TSS-500 bp-TSS of genes that are significantly down-regulated or for a same number of genes which RNA levels are not modified in shTop1 versus shCtrl HCT116 cells.
Databáze: OpenAIRE