Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Lidocaine/Tetracaine Patch for Induction of Local Anesthesia prior to Minor Dermatologic Procedures in Geriatric Patients
| Autor: | Robert J. Pariser, Neil S. Sadick, Mark Ling, Amy K. Schecter, Daniel Stewart, David M. Pariser |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Lidocaine Tetracaine medicine.drug_class Visual analogue scale Biopsy Dermatology Placebo Skin Diseases law.invention Randomized controlled trial Double-Blind Method law medicine Humans Local anesthesia Anesthetics Local Shave biopsy Aged Pain Measurement medicine.diagnostic_test Local anesthetic business.industry General Medicine Surgery Drug Combinations Cryotherapy Anesthesia Female business medicine.drug |
| Zdroj: | Dermatologic Surgery. 31:287-291 |
| ISSN: | 1076-0512 |
| DOI: | 10.1097/00042728-200503000-00006 |
| Popis: | Background Topical anesthetics offer a noninvasive method of anesthesia. Objective To evaluate the efficacy and safety of the lidocaine/tetracaine patch, a 1:1 (wt:wt) eutectic mixture of lidocaine and tetracaine, for local anesthesia before minor dermatologic procedures in geriatric patients. Methods In a multicenter, randomized, double-blind, placebo-controlled study, 79 patients over the age of 65 years received a 30-minute application of either the lidocaine/tetracaine patch or placebo immediately before a shave biopsy or superficial excision. The primary measure of efficacy was patient assessment of procedural pain using the visual analog scale (VAS). Secondary efficacy end points included patient, investigator, and independent observer assessments. Results There was a statistically significant difference (p= .041) in patient ratings of pain by VAS score in the active group (9.5 mm) compared with the placebo group (22.5 mm). None of the secondary end points showed a statistically significant difference between groups. No adverse events were reported. Conclusion The lidocaine/tetracaine patch is a safe and effective method for noninvasive induction of local anesthesia for minor dermatologic procedures in patients over the age of 65 years. RESEARCH FUNDING WAS RECEIVED FROM ZARS, INC., SALT LAKE CITY, UTAH. |
| Databáze: | OpenAIRE |
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