Unified synthesis of tirandamycins and streptolydigins
| Autor: | Hikaru Yoshimura, Jun Ishihara, Keisuke Takahashi, Susumi Hatakeyama |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
biology
Chemistry Stereochemistry Metals and Alloys Cinchona Stereoisomerism General Chemistry Tirandalydigin biology.organism_classification Bridged Bicyclo Compounds Heterocyclic Catalysis Pyrrolidinones Surfaces Coatings and Films Electronic Optical and Magnetic Materials Anti-Bacterial Agents Aminoglycosides Materials Chemistry Ceramics and Composites medicine Hydrogenation Streptolydigin medicine.drug |
| Zdroj: | Chemical communications (Cambridge, England). 51(95) |
| ISSN: | 1364-548X |
| Popis: | The asymmetric total syntheses of tirandamycins A–D and tirandalydigin as well as the synthesis of the left-hand fragment of streptolydiginone and streptolydigin from a common intermediate are described. The comprehensive approach features the highly enantio- and diastereoselective assembly of the anti,anti,syn-stereotetrad unit which relies on a cinchona alkaloid-catalyzed asymmetric Morita–Baylis–Hillman reaction. |
| Databáze: | OpenAIRE |
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