Pre-implantation genetic testing for aneuploidy: motivations, concerns, and perceptions in a UK population

Autor: Srdjan Saso, Lorraine Kasaven, Benjamin P Jones, Maria Jalmbrant, Jara Ben Nagi, Paul Serhal, Diana Marcus, Timothy Bracewell-Milnes, Megan Spearman, Ariadne L'Heveder, Joy Green, Rabi Odia
Rok vydání: 2021
Předmět:
Adult
0301 basic medicine
Infertility
medicine.medical_specialty
Pre-implantation genetic testing for aneuploidies
Pregnancy Rate
medicine.medical_treatment
Population
Reproductive medicine
Fertilization in Vitro
03 medical and health sciences
0302 clinical medicine
In vitro fertilisation
Pregnancy
Genetics
Perceptions
Humans
Medicine
Embryo Implantation
Genetic Testing
education
Preimplantation Diagnosis
Genetics (clinical)
Genetic testing
Motivation
education.field_of_study
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
Obstetrics and Gynecology
General Medicine
Aneuploidy
Embryo Transfer
medicine.disease
United Kingdom
Embryo transfer
Fertility clinic
030104 developmental biology
Reproductive Medicine
IVF
Female
business
Live birth
PGT-A
Developmental Biology
Demography
Zdroj: Journal of Assisted Reproduction and Genetics
ISSN: 1573-7330
1058-0468
Popis: PurposePre-implantation genetic testing for aneuploidies (PGT-A) is a technique used as part of in vitro fertilisation to improve outcomes. Despite the upward trend in women utilising PGT-A, data on women’s motivations and concerns toward using the technology, and perceptions having undergone the process, remain scarce.MethodsThis cross-sectional survey, based at a fertility clinic in the UK, utilised an electronic questionnaire to assess the motivations of women who undergo PGT-A and their perceptions and attitudes toward PGT-A after using it.ResultsOne hundred sixty-one women responded. The most significant motivating factors to undergo PGT-A were to improve the probability of having a baby per cycle (9.0 ± 2.1) and enhance the chance of implantation (8.8 ± 2.5). The least important motivations were reducing the number of embryos transferred per cycle (2.7 ± 3.3) and saving money by reducing the number of procedures required (4.6 ± 3.4). The most significant concerning factors identified included not having embryos to transfer (5.7 ± 3.4) and the potential for embryo damage (5.2 ± 3.3). The least concerning factors included religious (0.6 ± 1.7) or moral (1 ± 2.2) concerns. The majority of women were satisfied/very satisfied following treatment (n= 109; 68%). The proportion of those who were satisfied/very satisfied increased to 94.2% (n= 81) following a successful outcome, and reduced to 43.5% (n= 27) in those who had an unsuccessful outcome or had not undergone embryo transfer (p< 0.001).ConclusionThis study highlights that perceptions amongst women who use PGT-A are mostly positive. We also demonstrate a significant association between satisfaction and reproductive outcomes, with those who achieve a live birth reporting more positive perceptions toward PGT-A.
Databáze: OpenAIRE
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