Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers

Autor: S. Katharine Hammond, Daniel E. Weiner, Michael P. LaValley, Katie M. Applebaum, Deepika Shrestha, Sa Liu, Ellen A. Eisen
Rok vydání: 2016
Předmět:
Oncology
Male
Michigan
Time Factors
Kidney Disease
Cumulative Exposure
Other Commerce
0302 clinical medicine
Risk Factors
2.2 Factors relating to the physical environment
Registries
Prospective Studies
Aetiology
Prospective cohort study
Cancer
African Americans
Incidence (epidemiology)
Incidence
Hazard ratio
Middle Aged
030210 environmental & occupational health
Management
Occupational Diseases
Metals
030220 oncology & carcinogenesis
Cohort
Metallurgy
Public Health and Health Services
Female
Environmental Monitoring
Adult
medicine.medical_specialty
Clinical Sciences
Article
White People
Environmental & Occupational Health
03 medical and health sciences
Internal medicine
Occupational Exposure
medicine
Humans
Tourism and Services
Carcinoma
Renal Cell
Proportional Hazards Models
Aged
Proportional hazards model
business.industry
Whites
Prevention
Carcinoma
Public Health
Environmental and Occupational Health
Renal Cell
Confidence interval
Surgery
Cancer registry
Black or African American
business
Automobiles
Zdroj: Occupational and environmental medicine, vol 73, iss 10
Popis: Objectives Metalworking fluids (MWF), used to cool and lubricate metal in occupational settings, are linked to several cancers but data on kidney cancer are limited. We examine how MWF influence the rate of renal cell carcinoma (RCC) in a large prospective study. Methods A cohort of Michigan autoworkers consisting of 33 421 individuals was followed from 1985 to 2009. The cohort was linked to the Michigan Cancer Registry to identify new cases of RCC. We analysed RCC in relation to cumulative exposure to each specific type of MWF (straight, soluble and synthetic) and all 3 types pooled into a single MWF variable, with a 15-year lag. Cox proportional hazards regression with splines were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), controlling for age, gender, race, calendar year, year hired, time since hire, plant and other MWF types. Results There were 135 incident cases. A linear increase in the log-HR was observed for RCC with increasing cumulative exposure to each MWF type and total MWF exposure. At the mean of total MWF exposure (18.80 mg/m 3 -year), the estimated HR was 1.11 (95% CI 1.04 to 1.19). Conclusions Our results provide evidence for a dose-dependent association between MWF exposure and RCC. The influence of components of oil-based and water-based MWF needs further examination.
Databáze: OpenAIRE
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