Anticough and antimicrobial activities of Psidium guajava Linn. leaf extract
| Autor: | Penchom Peungvicha, Paranee Khoohaswan, Potjanee Suriyawong, Y. Wongkrajang, Pranee Jaiarj, M.L. Sumal Saraya, Orawan Ruangsomboon |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Staphylococcus aureus Microbial Sensitivity Tests Biology medicine.disease_cause Mice Smooth muscle Drug Discovery Botany medicine Animals Humans Rats Wistar Antibacterial agent Pharmacology Psidium Dose-Response Relationship Drug Traditional medicine Plant Extracts Myrtaceae Muscle Smooth Antimicrobial biology.organism_classification Acute toxicity Anti-Bacterial Agents Rats Plant Leaves Trachea Antitussive Agents Dose–response relationship Cough Female Capsaicin Muscle Contraction |
| Zdroj: | Journal of Ethnopharmacology. 67:203-212 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/s0378-8741(99)00022-7 |
| Popis: | The anticough activity of Psidium guajava Linn. (guava) leaf extract was evaluated in rats and guinea pigs. The results showed that water extract of the plant at doses of 2 and 5 g/kg, p.o. decreased the frequency of cough induced by capsaicin aerosol by 35 and 54%, respectively, as compared to the control, within 10 min after injection of the extract, (P0.01). However, the anticough activity is less potent than that of 3 mg/kg dextromethorphan which decreased frequency of cough by 78% (P0.01). An experiment on isolated rat tracheal muscle showed that the extract directly stimulated muscle contraction and also synergized with the stimulatory effect of pilocarpine. This effect was antagonized by an atropine. Moreover, growth of Staphylococcus aureus and beta-streptococcus group A, as determined by the disc diffusion method, was inhibited by water, methanol and chloroform extract of dry guava leaves (P0.001). The LD50 of guava leaf extract was more than 5 g/kg, p.o. These results suggest that guava leaf extract is recommended as a cough remedy. |
| Databáze: | OpenAIRE |
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