Ghost cell glaucoma after intravitreous injection of ranibizumab in proliferative diabetic retinopathy

Autor: Jun Xu, Jipeng Li, Ning pu Liu, Meng Zhao
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Intraocular pressure
genetic structures
medicine.medical_treatment
Vitrectomy
Angiogenesis Inhibitors
Retinal Neovascularization
03 medical and health sciences
Tonometry
Ocular
0302 clinical medicine
lcsh:Ophthalmology
Ophthalmology
Ranibizumab
medicine
Proliferative diabetic retinopathy
Humans
In patient
030212 general & internal medicine
Intraocular Pressure
Aged
Retrospective Studies
Diabetic Retinopathy
Ghost cell glaucoma
business.industry
Glaucoma
General Medicine
Diabetic retinopathy
Middle Aged
medicine.disease
eye diseases
medicine.anatomical_structure
lcsh:RE1-994
Intravitreal Injections
030221 ophthalmology & optometry
Intravitreous injection
Female
sense organs
business
medicine.drug
Optic disc
Case series
Research Article
Zdroj: BMC Ophthalmology
BMC Ophthalmology, Vol 20, Iss 1, Pp 1-7 (2020)
ISSN: 1471-2415
Popis: Background The development of ghost cell glaucoma in patients with proliferative diabetic retinopathy (PDR) after intravitreous injection (IV) was rare. Here we reported a series of patients with PDR who received Intravitreous Ranibizumab (IVR) and developed ghost cell glaucoma and analyzed the potential factors that might be related to the development of ghost cell glaucoma. Methods Retrospective case series study. The medical records of 71 consecutive eyes of 68 PDR patients who received vitrectomy after IVR from January 2015 to January 2017 were reviewed. The development of ghost cell glaucoma after IVR was recorded. Characteristics of enrolled patients were retrieved from their medical charts. Factors associated with ghost cell glaucoma were compared between eyes with the development of ghost cell glaucoma and eyes without the development of ghost cell glaucoma. Variables were further enrolled in a binary backward stepwise logistic regression model, and the model that had the lowest AIC was chosen. Results There were 8 out of 71 eyes of the PDR patients developed ghost cell glaucoma after they received IVR. The interval between detection of elevation of intraocular pressure (IOP) and IV ranged from 0 to 2 days. Among them, after IVR, there were two eyes had IOP greater than 30 mmHg within 30 min, four eyes showed normal IOP at 30 min, and then developed ghost cell glaucoma within 1 day, two eyes developed ghost cell glaucoma between 24 and 48 h. The mean IOP was 46.5 ± 8.0 mmHg. All patients gained normal IOP after vitrectomy without medicine for lowering IOP. The presence of ghost cell glaucoma was associated with tractional retinal detachment (RR = 4.60 [2.02 ~ 8.48], p = 0.004) and fibrovascular membrane involving disk (RR = -3.57 [− 7.59 ~ − 0.92], p = 0.03) (AIC = 39.23, AUC = 0.88) in a logistic regression model. Conclusion Attention to postoperative IOP should be paid to patients with PDR undergoing vitrectomy who receive a preoperative IV of anti-VEGF agents. PDR patients with tractional retinal detachment or fibrovasucular membrane involving optic disc are more likely to develop ghost cell glaucoma after IV.
Databáze: OpenAIRE
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