In situ accurate deposition of electrospun medical glue fibers on kidney with auxiliary electrode method for fast hemostasis
| Autor: | Luo Weiling, Jun Zhang, Jiang-Jun Liu, Xuan Qiu, Peng-Yue Hu, Seeram Ramakrishna, Xiao-Fei Liu, Yun-Ze Long, Miao Yu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Auxiliary electrode Materials science Swine Bioengineering 02 engineering and technology Kidney 010402 general chemistry 01 natural sciences Rats Sprague-Dawley Biomaterials Adhesives Spectroscopy Fourier Transform Infrared Animals Deposition (phase transition) Fiber GLUE Electrodes Spinning Hemostasis 021001 nanoscience & nanotechnology Electroplating Electric Stimulation Electrospinning Blood Cell Count 0104 chemical sciences Mechanics of Materials Electrode 0210 nano-technology Biomedical engineering |
| Zdroj: | Materials Science and Engineering: C. 101:380-386 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2019.03.075 |
| Popis: | An auxiliary electrode electrospinning method is proposed to deposit N-octyl-2-cyanoacrylate (NOCA) medical glue fibrous membrane on kidney for in-situ fast hemostasis. A metal electrode equipped to the spinning needle is used to confine the divergence angle of jet. Compared to the conventional electrospinning method, the fiber deposition area has reduced by 2.5 times, and it can achieve in-situ accurate deposition. Moreover, it reduces both the external dimension and over-reliance on electricity, which is superior to previous air-flow assisted electrospinning method. In addition, in situ accurate deposition of NOCA on the kidney exhibits fast hemostasis within 10 s, confirming that this auxiliary electrode method can be applied in outdoors for fast hemostasis. Further pathological studies indicate that this auxiliary electrode method can reduce the inflammatory response of tissues due to the better accurate deposition. This portable hand-held device with the auxiliary electrode method may have potential application in fast hemostasis for outdoors due to its accurate deposition and portability characteristics. |
| Databáze: | OpenAIRE |
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