Preoperative platelet morphology parameters as prognostic predictors for endometrial malignant carcinoma stage and progesterone receptor
| Autor: | Jiangcheng Su, Jianrong Song, Yulong Zhang, Xiangqin Zheng, Xiaohong Lai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood Platelets
medicine.medical_specialty predictive factors Platelet Function Tests medicine.medical_treatment Observational Study Hysterectomy Gastroenterology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine White blood cell Progesterone receptor medicine Carcinoma Humans 030212 general & internal medicine Radical surgery Mean platelet volume Neoplasm Staging Retrospective Studies platelet morphology business.industry Platelet Distribution Width General Medicine Middle Aged medicine.disease Prognosis Endometrial Neoplasms medicine.anatomical_structure endometrial disease 030220 oncology & carcinogenesis Predictive value of tests Preoperative Period Female business platelet indices Receptors Progesterone Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | To investigate preoperative platelet morphology parameters and other whole blood cells in patients of malignant endometrial carcinoma compared with benign disease. Retrospective analysis was performed through collecting patients’ hematological parameters before performing total abdominal/vaginal hysterectomy and standard radical surgery due to benign and malignant endometrial disease between 2006 and 2017. Parameters required included white blood cell (WBC), hemoglobin, platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and platelet thrombocytocrit (PCT). And neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated. For malignant carcinoma, Ki-67 percentage and progesterone receptor (PR) status were further collected. A total of 288 patients were included with 145 benign cases and 143 malignant cases. Patients of confirmed endometrial carcinoma showed a significant lower value of PDW (55.21 ± 4.72 vs 49.54 ± 5.89, P .05), while increased value in PDW and reduced value in MPV was found in PR negative compared with positive patients. Preoperative platelet morphology parameters seemed to be used as one kind of predictive factors to discriminate malignant and benign endometrial disease. Limited by present study design, further prospective studies are required to support this finding. |
| Databáze: | OpenAIRE |
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