Role of thePROS1gene in thrombosis: lessons and controversies
| Autor: | Mary J. Heeb |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.drug_class
Coenzymes medicine.disease_cause Article Protein S medicine Humans Mutation biology business.industry Anticoagulant Anticoagulants Thrombosis PROS1 Gene Blood Proteins Hematology medicine.disease Phenotype Apoptosis Immunology Cancer research biology.protein business Protein C medicine.drug |
| Zdroj: | Expert Review of Hematology. 1:9-12 |
| ISSN: | 1747-4094 1747-4086 |
| Popis: | The PROS1 gene codes for the vitaminK-dependent plasma protein, protein S (PS), an essential anticoagulant and multifunctional protein. The association of PS with thrombosis [1] is well established, but the particular anticoagulant activity or activities of PS that are compromised in thrombosis are not entirely clear and the effects of PS deficiency on more recently discovered functions of PS in inflamma tion, apoptosis and receptor activation are unknown. Lessons can be learned from the phenotypes of reported mutations and polymorphisms in the PROS1 gene, but many questions and controversies remain. For greater depth, the reader is referred to extensive databases of PS mutations [2,3], recent reviews [4,5] and molecular models that rationalize PS mutations [6,7]. PS cofactor activity for activated protein C |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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