Primary tumor resection improves prognosis of unresectable carcinomas of the transverse colon including flexures with liver metastasis: a preliminary population-based analysis
| Autor: | Rui Sun, Chao Huang, Jiefeng Zhao, Zhengming Zhu, Jinfeng Zhu, Rongfa Yuan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Survival Colorectal cancer medicine.medical_treatment Gastroenterology Metastasis Splenic flexure Young Adult Surgical oncology Internal medicine Genetics medicine Humans Transverse colon Colectomy RC254-282 Aged Aged 80 and over business.industry Liver Neoplasms Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged Prognosis medicine.disease Primary tumor Carcinoembryonic Antigen SEER Colorectal cancer liver metastasis Hepatic flexure Oncology Colonic Neoplasms Female Primary tumor resection business Colon Transverse Research Article |
| Zdroj: | BMC Cancer, Vol 21, Iss 1, Pp 1-18 (2021) BMC Cancer |
| ISSN: | 1471-2407 |
| Popis: | Purpose Studies on unresectable colorectal cancer liver metastasis(CRLM) rarely analyze the prognosis of the patients from the point of colonic subsites. We aimed to evaluate the effect of primary tumor resection (PTR) and different scope of colectomy on the prognosis of patients with unresectable transverse colon cancer liver metastasis (UTCLM), hepatic flexure cancer liver metastasis (UHFLM), and splenic flexure cancer liver metastasis (USFLM). Patients and methods The patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Cox proportional hazards regression models were used to identify prognostic factors of overall survival (OS) and cause-specific survival (CSS). Kaplan-Meier analyses and log-rank tests were conducted to assess the effectiveness of PTR on survival. Results In total, this study included a cohort of 1960 patients: 556 cases of UHFLM, 1008 cases of UTCLM, and 396 cases of USFLM. The median survival time of whole patients was 11.0 months, ranging from 7.0 months for UHFLM patients to 15.0 months for USFLM patients. USFLM patients had the best OS and CSS, followed by UTCLM patients. UHFLM patients had the worst OS and CSS (All P P Conclusions We confirmed the different survival of patients with UTCLM, UHFLM, and USFLM, and for the first time, we proved that PTR could provide survival benefits for patients with unresectable CRLM from the perspective of colonic subsites of transverse colon, hepatic flexure, and splenic flexure. Besides, PTR may not improve the prognosis of USFLM patients with CEA- negative or tumor size≤5 cm. For oncologic outcomes, we concluded that segmental colon resection seemed an effective surgical procedure for UTCLM, UHFLM, and USFLM. |
| Databáze: | OpenAIRE |
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