Membranoproliferative glomerulonephritis: current histopathological classification, clinical profile, and kidney outcomes
| Autor: | Thaíza Passaglia Bernardes, Gianna Mastroianni-Kirsztajn |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Nephrology n.ahead 2022 Jornal Brasileiro de Nefrologia Sociedade Brasileira de Nefrologia (SBN) instacron:SBN Brazilian Journal of Nephrology, Issue: ahead, Published: 27 JUN 2022 Brazilian Journal of Nephrology, Volume: 45, Issue: 1, Pages: 45-50, Published: 27 JUN 2022 |
| ISSN: | 2175-8239 |
| Popis: | Introduction: Membranoproliferative glomerulonephritis (MPGN) is a rare glomerular disease with a variable prognosis. A new classification based on the presence or absence of immunoglobulins and complement deposits in immunofluorescence microscopy (IF) of kidney biopsy has recently been proposed. The objectives of the study were to determine and compare the clinical, laboratory, and histopathological characteristics of those with primary or secondary MPGN, reclassify the primary ones based on IF findings, and evaluate kidney outcomes. Methods: This was an observational retrospective cohort study carried out in a single center (UNIFESP), based on the data collected from medical records of patients followed from 1996 to 2019. Results: Of 53 cases of MPGN, 36 (67.9%) were classified as primary and 17 (32.1%) as secondary MPGN. Most patients were hypertensive (84.9%) and had edema (88.7%) and anemia (84.9%); 33 (91.7%) patients classified as primary MPGN were reclassified as immune-complex-mediated and 3 (8.3%) as complement-mediated. The secondary MPGN group had hematuria more frequently (p |
| Databáze: | OpenAIRE |
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