Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease
| Autor: | Sungha Park, Bok Ghee Han, Jong-Keuk Lee, Jong-Young Lee, Ha Jung Ryu, Hung Tae Kim, Seung Hun Cha, Hyung Doo Shin, Jun Woo Kim, Kuchan Kimm, Bermseok Oh, Byung Lae Park, Yangsoo Jang, Hyun Young Park |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Receptors CCR2 Clinical Biochemistry Single-nucleotide polymorphism Coronary Artery Disease Polymorphism Single Nucleotide Biochemistry Coronary artery disease Pathogenesis Internal medicine Humans Medicine SNP Genetic Predisposition to Disease Korea business.industry Biochemistry (medical) General Medicine Odds ratio Middle Aged medicine.disease medicine.anatomical_structure Haplotypes Genetic marker Cardiology Receptors Chemokine business Artery |
| Zdroj: | Clinica Chimica Acta. 382:129-133 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2007.03.017 |
| Popis: | Coronary artery disease (CAD) is one of the most common forms of heart disease. It has been demonstrated that chemokine-mediated inflammation is associated with the development of CAD. In this study, in order to determine the role of CCR2, a receptor for MCP-1, in the development of CAD, we initially sequenced and identified the genetic variants of CCR2 using 24 unrelated Korean individuals' DNA samples. A total of 13 genetic variants, including 1 deletion and 12 SNPs, were identified in the Korean population. Although we could not detect any association of CCR2 polymorphic markers with CAD, several SNP markers of CCR2 gene showed highly significant signals with the number of arteries with significant coronary artery stenosis in the CAD male patients. The most significant signal was detected at the SNP located at exon 2 (+780T>C, Asn260Asn) CI: 1.19-1.87, P=0.0005 (odds ratio: 1.49, 95% CI: 1.19-1.87, p=0.0005) (Table 3). This result indicates that CCR2 can play a role in the pathogenesis of CAD, especially to the number of vessels in CAD. |
| Databáze: | OpenAIRE |
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