Characteristics of subjective cognitive decline associated with amyloid positivity
| Autor: | Janssen, Olin, Jansen, Willemijn J, Epelbaum, Stéphane, Lleó, Alberto, Engelborghs, Sebastiaan, van der Flier, Wiesje M, Landau, Susan, Popp, Julius, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J, Vos, Stephanie J B, Rowe, Chris, Chételat, Gaël, Ruíz, Agustin, Marquié, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael, Boecker, Henning, Peters, Oliver, Jarholm, Jonas, Boada, Merce, Rami, Lorena, Tort-Merino, Adrià, Binette, Alexa Pichet, Poirier, Judes, Rosa-Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel, Fortea, Juan, Parnetti, Lucilla, Sánchez-Saudinós, M Belén, Ebenau, Jarith, Pocnet, Cornelia, Eckerström, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund-Levi, Yvonne, Gabryelewicz, Tomasz, Wallin, Åsa K, Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald, Spiru, Luiza, Initiative, Alzheimer's Disease Neuroimaging, group, FACEHBI study, group, PREVENT-AD research, Tijms, Betty, Fladby, Tormod, Ossenkoppele, Rik, Verhey, Frans R J, Jessen, Frank, Visser, Pieter Jelle, Molinuevo, José Luis, Villeneuve, Sylvia, Hort, Jakub |
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| Přispěvatelé: | RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, Neurology, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Brain Imaging, Alzheimers Dis Neuroimaging Initia, Facehbi Study Grp, PREVENT-AD Res Grp, Clinical sciences, Neuroprotection & Neuromodulation |
| Rok vydání: | 2022 |
| Předmět: |
PRECLINICAL ALZHEIMERS-DISEASE
Amyloid SYMPTOMS positron emission tomography Epidemiology Neuroscience(all) Apolipoprotein E4 Amyloidogenic Proteins cerebrospinal fluid Cellular and Molecular Neuroscience Developmental Neuroscience mental disorders Humans Cognitive Dysfunction ddc:610 DEPOSITION OLDER-ADULTS genetics [Apolipoprotein E4] POPULATION RISK neurology Health Policy DEMENTIA genetics [Cognitive Dysfunction] Brain amyloid Amyloidosis Alzheimer's disease PREVALENCE COMMUNITY Psychiatry and Mental health metabolism [Brain] Positron-Emission Tomography Neurology (clinical) Human medicine psychology [Cognitive Dysfunction] Geriatrics and Gerontology subjective cognitive decline MEMORY COMPLAINTS Biomarkers |
| Zdroj: | Alzheimers & Dementia r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Universidad Europea (UEM) PREVENT-AD Research Group, Alzheimer's Disease Neuroimaging Initiative & FACEHBI study group 2021, ' Characteristics of subjective cognitive decline associated with amyloid positivity ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12512 Alzheimer's & Dementia, 18, 1832-1845. Elsevier Science Alzheimer's and dementia 18(10), 1832-1845 (2022). doi:10.1002/alz.12512 Alzheimer's and Dementia. Elsevier Alzheimer's & dementia |
| ISSN: | 1552-5260 |
| Popis: | Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals. |
| Databáze: | OpenAIRE |
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