Antistaphylococcal activities of quinupristin/dalfopristin in vitro across platelet-fibrin matrices and in experimental endocarditis
| Autor: | N Diallo, J. F. Desnottes, Y Huet, N Berthaud |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Microbiology (medical)
Blood Platelets Male Staphylococcus aureus medicine.medical_treatment Colony Count Microbial Dalfopristin Microbial Sensitivity Tests medicine.disease_cause Virginiamycin Microbiology chemistry.chemical_compound Vancomycin polycyclic compounds medicine Endocarditis Animals Pharmacology (medical) Antibacterial agent Pharmacology business.industry Quinupristin Endocarditis Bacterial biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents Quinupristin/dalfopristin Infectious Diseases chemistry Methicillin Resistance Rabbits business medicine.drug |
| Zdroj: | The Journal of antimicrobial chemotherapy. 39 |
| ISSN: | 0305-7453 |
| Popis: | In-vitro and in-vivo efficacies of quinupristin/dalfopristin and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) responsible for endocarditis have been compared. The following parameters were investigated: MIC, activity across a platelet-fibrin matrix simulating cardiac vegetations, killing of bacteria on the cardiac vegetations resulting from experimental aortic valve endocarditis in an animal model, and concentrations of antibiotics in the serum and vegetations of infected rabbits. The same bacterial strain was used for all experiments. The MICs of quinupristin/dalfopristin and vancomycin were 0.25 and 1 mg/L, respectively. When tested for their ability to penetrate platelet-fibrin matrices, both drugs were bactericidal against the MRSA strain (> or = 2 log10 cfu/mL decrease in 2 h). Both drugs significantly reduced the bacterial counts in vegetations in infected rabbits. Within 12 h of intravenous administration of 20 mg/kg, concentrations of quinupristin/dalfopristin decreased from 5.3 to < 0.10 mg/L in serum and from 12.9 to < 1 mg/kg in the valve vegetations. Although the concentrations of vancomycin in the serum and the infected tissue were higher than those of quinupristin/dalfopristin, the latter combination was equally effective, perhaps because its bactericidal activity is rapid and because it can more easily penetrate the cardiac vegetations. |
| Databáze: | OpenAIRE |
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