The impact of native leptomeningeal collateralization on rapid blood flow recruitment following ischemic stroke
| Autor: | Atsushi Kanoke, Eric To, Teiji Tominaga, Yuandong Li, Jialing Liu, Ruikang K. Wang, Yosuke Akamatsu, Yasuo Nishijima, Chih C Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Doppler OCT
medicine.medical_specialty Computed Tomography Angiography Ultrasonography Doppler Transcranial Collateral Circulation 030204 cardiovascular system & hematology Independent predictor Brain Ischemia Mice 03 medical and health sciences Meninges 0302 clinical medicine Internal medicine Stroke outcome Animals Medicine Mice Inbred BALB C medicine.diagnostic_test business.industry Brain Genetic Variation Infarction Middle Cerebral Artery Original Articles Blood flow Mice Inbred C57BL Stroke Disease Models Animal Neurology Cerebrovascular Circulation Angiography Ischemic stroke Cardiology Disease Susceptibility Neurology (clinical) Cardiology and Cardiovascular Medicine business Collateralization Blood Flow Velocity Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | J Cereb Blood Flow Metab |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1177/0271678x20941265 |
| Popis: | The leptomeningeal collateral status is an independent predictor of stroke outcome. By means of optical coherent tomography angiography to compare two mouse strains with different extent of native leptomeningeal collateralization, we determined the spatiotemporal dynamics of collateral flow and downstream hemodynamics following ischemic stroke. A robust recruitment of leptomeningeal collateral flow was detected immediately after middle cerebral artery (MCA) occlusion in C57BL/6 mice, with continued expansion over the course of seven days. In contrast, little collateral recruitment was seen in Balb/C mice during- and one day after MCAO, which coincided with a greater infarct size and worse functional outcome compared to C57BL/6, despite a slight improvement of cortical perfusion seven days after MCAO. Both strains of mice experienced a reduction of blood flow in the penetrating arterioles (PA) by more than 90% 30-min after dMCAO, although the decrease of PA flow was greater and the recovery was less in the Balb/C mice. Further, Balb/C mice also displayed a prolonged greater heterogeneity of capillary transit time after dMCAO in the MCA territory compared to C57BL/6 mice. Our data suggest that the extent of native leptomeningeal collaterals affects downstream hemodynamics with a long lasting impact in the microvascular bed after cortical stroke. |
| Databáze: | OpenAIRE |
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